249 research outputs found

    Introduction

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    A data-driven model inversion approach to cancer immunotherapy control

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    A novel data-driven control design approach for Multiple Input Multiple Output nonlinear systems is proposed in the paper, relying on the identification of a polynomial prediction model of the system to control and its on-line inversion. A simulated study is then presented, concerning the design of a control strategy for cancer immunotherapy. This study shows that the proposed approach may be quite effective in treating cancer patients, and may give results similar to (or perhaps better than) those provided by “standard” methods. The fundamental difference is that “standard” methods are typically based on the unrealistic assumption that an accurate physiological model of the cancer-immune mechanism is avail- able; in the approach proposed here, the controller is designed without such a strong assumption

    Control of systems with sector-bounded nonlinearities: robust stability and command effort minimization by disturbance rejection

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    The paper shows that a control strategy with disturbance rejection is able to reduce the control effort to a minimum, ensuring at the same time a desired performance level. The disturbance to be rejected is completely unknown except for a sectorial bound. The control unit is endowed with an extended state observer which includes a disturbance dynamics, whose state tracks the unknown disturbance to be rejected. In summary, the novel contributions of the paper are the following. First, we derive a robust stability condition for the proposed control scheme, holding for all the nonlinearities that are bounded by a known (or estimated) maximum slope. Second, we propose a novel approach for designing the observer and state feedback gains, which guarantee robust closed-loop stability. Third, we show that the designed control system yields, with a minimum control effort, the same control performance as a robust state feedback control, which on the contrary may require a larger command activity. Two simulated case studies are presented to show the effectiveness of the proposed approach

    Experimental modeling of a web-winding machine: LPV approaches

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    This chapter presents the identification of a web-winding system as a linear parameter varying (LPV) system with the reel radius as the time-varying parameter. This system is nonlinear, time-varying and input–output unstable. Two identification methods are considered: in the first one, an LPV model is estimated in a single step using a novel approach based on sparse identification and set membership optimality evaluation. In the second one, several local linear time-invariant (LTI) models are identified using classical identification algorithms, and the overall LPV model is constructed as a weighted sum of the local models. The two methods are applied to experimental data measured on a real web-winding machine
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